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Updating systematic reviews

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We prepare and disseminate evidence-based, regularly updated reviews of the effects of therapies in neonatal-perinatal medicine.

They are a significant piece of work (the Centre for Reviews and Dissemination at York estimates that a team will take 9-24 months), and to be useful to other researchers and practitioners they should have: It is essential that each review is approached rigorously and with careful attention to detail. The consensus reporting guidelines for different study designs proposed by EQUATOR ( are a useful starting point. If you are proposing to perform a systematic review these provide invaluable detailed advice, and useful examples.Electronic searches with Me SH terms and text words identified 3115 papers.Two independent reviewers assessed study quality and performed data extraction.Pooled percentage prevalence of resistance to the most commonly used antibiotics in children in primary care, stratified by the OECD (Organisation for Economic Co-operation and Development) status of the study country.Random effects meta-analysis was used to quantify the association between previous exposure to antibiotics in primary care and resistance.This approach ensures that infectious agents, whether common (e.g. influenza or multi-resistant organisms [MROs]), can be managed effectively.